Falcipain cysteine proteases of malaria parasites: An update

Rosenthal Philip J.

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Falcipain cysteine proteases of malaria parasites: An update

机译：疟疾寄生虫的恶毒脂雀半胱氨酸蛋白酶：更新

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Background: The malaria parasite Plasmodium falciparum expresses four related papain-family cysteine proteases known as falcipains. These proteases play critical roles in the parasite life cycle, and as such are potential targets for new modes of antimalarial chemotherapy, as discussed in this review.

机译：背景：疟疾寄生虫疟原虫疟原虫表达四种相关的蛋白石 - 家族半胱氨酸蛋白酶，称为恶毒素。这些蛋白酶在寄生虫生命周期中发挥着关键作用，因此，如本综述所讨论的，这种潜在的抗疟过程模式的潜在目标。

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《Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics》 |2020年第3期|共5页
作者
Rosenthal Philip J.;
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作者单位

Univ Calif San Francisco Dept Med San Francisco CA 94143 USA;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Falcipain; Malaria; Plasmodium; Protease; Papain; Hemoglobin;

机译：恶霸;疟疾;疟原虫;蛋白酶;木瓜蛋白酶;血红蛋白;

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1. Falcipain cysteine proteases of malaria parasites: An update [J] . Rosenthal Philip J. Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2020,第3期

机译：疟疾寄生虫的恶毒脂雀半胱氨酸蛋白酶：更新
2. A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development [J] . Korde R, Bhardwaj A, Singh R, Journal of Medicinal Chemistry . 2008,第11期

机译：恶性疟原虫半胱氨酸蛋白酶的前结构域肽（falcipain-2）抑制疟原虫的发展
3. Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum. [J] . Dasaradhi PV, Korde R, Thompson JK, Molecular and Biochemical Parasitology . 2007,第1期

机译：食品液泡靶向和贩运falcipain-2，falcipain-2是人疟疾寄生虫恶性疟原虫的重要半胱氨酸蛋白酶。
4. Producing armyworm {spodoptera sp.) Bioinsecticide based on cysteine protease of red ginger {zingiber officinale var. Rubrum) [C] . N T Afnan, D F Nur, T S Utami International Conference on Quality in Research . 2018

机译：基于红姜的半胱氨酸蛋白酶生成生物灭菌剂{Zingiber Officinale VAR。 rubrum）
5. Use of structure-and ligand-based drug design tools for the discovery of small molecule inhibitors of cysteine proteases for the treatment of malaria and SARS infection. [D] . Shah, Falgun. 2011

机译：使用基于结构和配体的药物设计工具来发现用于治疗疟疾和SARS感染的半胱氨酸蛋白酶的小分子抑制剂。
6. Regulatory Elements within the Prodomain of Falcipain-2 a Cysteine Protease of the Malaria Parasite Plasmodium falciparum [O] . Kailash C. Pandey, David T. Barkan, Andrej Sali, 2009

机译：Falcipain-2（疟疾寄生虫恶性疟原虫的半胱氨酸蛋白酶）的前域内的调控元件
7. Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite Plasmodium falciparum [O] . Pandey, Kailash C., Barkan, David T., Sali, Andrej, 2009

机译：Falcipain-2（疟疾寄生虫恶性疟原虫的半胱氨酸蛋白酶）的前域内的调控元件

Falcipain cysteine proteases of malaria parasites: An update

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