IBX-promoted domino reaction of alpha-hydroxy amides: a facile one-pot synthesis of isatins

摘要

A novel and temperature-controlled oxidation of alpha-hydroxy amides in the presence of IBX is described. The divergent one-pot synthesis of isatins and alpha-formyl amides was achieved in good to excellent yields undermetal-free conditions. And these two mild methods can tolerate a variety of functional groups, and are operationally simple.