Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries

Wu Peng; Petersen Michael Axman; Petersen Rico; Flagstad Thomas; Guilleux Rachel; Ohsten Martin; Morgentin Remy; Nielsen Thomas E.; Clausen Mads H.

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Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries

机译：串联曼尼奇/导胶剂反应用于合成吲哚复合文库

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摘要

A tandem Mannich/Diels-Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a, 6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.

机译：本研究证明了用于合成吲哚-odaHydro-3a，6-环氧 - 异吲哚核心结构的小分子文库的串联曼尼奇/酰胺序列。进行基于该支架的代表性多样化示例，在欧洲领导工厂（ELF）联盟内正在生产文库。

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《RSC Advances》 |2016年第52期|共4页
作者
Wu Peng; Petersen Michael Axman; Petersen Rico; Flagstad Thomas; Guilleux Rachel; Ohsten Martin; Morgentin Remy; Nielsen Thomas E.; Clausen Mads H.;
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Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

EDELRIS 115 Ave Lacassagne F-69003 Lyon France;

EDELRIS 115 Ave Lacassagne F-69003 Lyon France;

EDELRIS 115 Ave Lacassagne F-69003 Lyon France;

Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

Tech Univ Denmark Dept Chem DK-2800 Lyngby Denmark;

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正文语种 eng
中图分类化学;
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1. Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries [J] . Wu Peng, Petersen Michael Axman, Petersen Rico, RSC Advances . 2016,第52期

机译：串联曼尼奇/导胶剂反应用于合成吲哚复合文库
2. Tandem Cross-Coupling/Spirocyclization/Mannich-Type Reactions of 3-(2-Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines [J] . Chen Guo-Shu, Chen Shu-Jie, Luo Jian, Angewandte Chemie . 2020,第2期

机译：串联交叉偶联/螺旋循环/曼尼希型反应3-（2-异氰基乙基）吲哚朝向多环螺吲哚啉
3. Tandem Cross-Coupling/Spirocyclization/Mannich-Type Reactions of 3-(2-Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines [J] . Chen Guo-Shu, Chen Shu-Jie, Luo Jian, Angewandte Chemie . 2020,第2期

机译：串联交叉偶联/螺旋循环/曼尼希型反应3-（2-异氰基乙基）吲哚朝向多环螺吲哚啉
4. Tandem Diels-Alder Reactions of Arynes: New Method for the Synthesis of Large Poly cyclic Aromatic Compounds and Nanographenes [C] . Diego Pena, Alejandro Criado, Dolores Perez European Symposium on Organic Chemistry . 2009

机译：Arynes的串联Diels-Alder反应：用于合成大聚环芳族化合物和纳米的新方法
5. I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions. II. Synthesis of pyrrolo[3,4-b]indoles. [D] . Kishbaugh, Tara Lynn Sanders. 2003

机译：I.缺电子的吲哚对亲核试剂，Diels-Alder反应和偶极环加成反应。二。吡咯并[3，4-b]吲哚的合成。
6. New synthesis of (±)-cis-trikentrin A via tandem indole aryne cycloaddition/Negishi reaction. Applications to library development [O] . Neil Brown, Diheng Luo, Joseph A. Decapo, -1

机译：的（±） - 顺式trikentrin经由串联吲哚环芳炔/根岸反应的新合成。应用对图书馆事业发展
7. Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries [O] . Wu Peng, Petersen Michael Åxman, Petersen Rico, 2016

机译：用于合成吲哚化合物库的Tandem mannich / Diels-alder反应

Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries

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