Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

Akiyama Goichi; Azuchi Yuriko; Guo Xiaoli; Noro Takahiko; Kimura Atsuko; Harada Chikako; Namekata Kazuhiko; Harada Takayuki

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Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

机译：依达拉华可防止视神经损伤后成人小鼠的视网膜变性

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PURPOSE. To assess the therapeutic potential of edaravone, a free radical scavenger that is used for the treatment of acute brain infarction and amyotrophic lateral sclerosis, in a mouse model of optic nerve injury (ONI).

机译：目的。为了评估埃达拉夫酮的治疗潜力，一种用于治疗急性脑梗塞和肌营养侧面硬化的自由基清除剂，在视神经损伤（ONI）的小鼠模型中。

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来源
《Investigative ophthalmology & visual science 》 |2017年第11期| 共7页
作者
Akiyama Goichi; Azuchi Yuriko; Guo Xiaoli; Noro Takahiko; Kimura Atsuko; Harada Chikako; Namekata Kazuhiko; Harada Takayuki;
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作者单位

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

Tokyo Metropolitan Inst Med Sci Visual Res Project Tokyo Japan;

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原文格式 PDF
正文语种 eng
中图分类眼科学 ;
关键词
edaravone; oxidative stress; neuroprotection; ASK1; retinal ganglion cell;

机译：埃达拉夫酮;氧化应激;神经保护;问1;视网膜神经节细胞;

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专利

1. Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury [J] . Goichi Akiyama, Yuriko Azuchi, Xiaoli Guo, Investigative ophthalmology & visual science . 2017 ,第11期

机译：依达拉奉预防视神经损伤后成年小鼠视网膜变性
2. Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury [J] . T Noro, K Namekata, A Kimura, Cell death & disease. . 2015 ,第4期

机译：亚精胺可促进成年小鼠视神经损伤后视网膜神经节细胞的存活和视神经再生
3. Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice (vol 170, pg 40, 2018) [J] . Experimental Eye Research . 2020 ,第期

机译：神经纤维层退化和视网膜神经节细胞损失长期视神经粉碎或成人小鼠横断（Vol 170，PG 40，2018）
4. Spontaneous Feedforward Connectivity in Electrically Stimulated Retinal Degeneration Mice* [C] . Stephen K. Agadagba, Leanne L.H. Chan Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2020

机译：电刺激视网膜变性小鼠的自发前馈连接*
5. In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model [D] . KITAMURA, Yuta 2019

机译：单一或联合使用局部神经保护和再生剂对大鼠视神经挤压模型中视网膜神经节细胞变性的体内作用
6. Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury [O] . T Noro, K Namekata, A Kimura, 2015

机译：亚精胺促进视神经损伤后成年小鼠的视网膜神经节细胞存活和视神经再生
7. Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury [O] . T Noro, K Namekata, A Kimura, 2015

机译：在视神经损伤后，硫胺促进成年小鼠中的视网膜神经节细胞存活和视神经再生

Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

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