A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema

Murugesan Nivetha; Clermont Allen C.; Rushbrooke Louise J.; Robson Peter A.; Thoonen Robrecht; Pethen Stephen J.; Hampton Sally L.; Feener Edward P.

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A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema

机译：一种新颖的口服血浆Kallikrein（PKAL）抑制剂KV123833阻断VEGF介导的视网膜水肿中的视网膜模型中的视网膜血管超甲型

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来源
《Investigative ophthalmology & visual science》 |2018年第9期|共3页
作者
Murugesan Nivetha; Clermont Allen C.; Rushbrooke Louise J.; Robson Peter A.; Thoonen Robrecht; Pethen Stephen J.; Hampton Sally L.; Feener Edward P.;
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KalVista Pharmaceut Cambridge MA USA;

Joslin Diabet Ctr Beetham Eye Inst Boston MA 02215 USA;

KalVista Pharmaceut Cambridge MA USA;

KalVista Pharmaceut Cambridge MA USA;

KalVista Pharmaceut Cambridge MA USA;

KalVista Pharmaceut Cambridge MA USA;

KalVista Pharmaceut Cambridge MA USA;

KalVista Pharmaceut Cambridge MA USA;

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正文语种 eng
中图分类眼科学;
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专利

1. A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema [J] . Murugesan Nivetha, Clermont Allen C., Rushbrooke Louise J., Investigative ophthalmology & visual science . 2018,第9期

机译：一种新颖的口服血浆Kallikrein（PKAL）抑制剂KV123833阻断VEGF介导的视网膜水肿中的视网膜模型中的视网膜血管超甲型
2. Plasma kallikrein (PKal) deficiency ameliorates the effects of vascular endothelial growth factor (VEGF) on retinal hyperpermeability and edema. [J] . Allen C Clermont, Qunfang Zhou, Nivetha Murugesan, Investigative ophthalmology & visual science . 2014,第13期

机译：血浆激肽释放酶（PKal）缺乏症改善了血管内皮生长因子（VEGF）对视网膜通透性和水肿的影响。
3. An orally dosed plasma kallikrein inhibitor decreases retinal vascular permeability in a rat model of diabetic retinopathy [J] . Calton Melissa A., Ma Jeffrey A., Chang Eric, Investigative ophthalmology & visual science . 2018,第9期

机译：口服血浆Kallikrein抑制剂在糖尿病视网膜病变大鼠模型中降低视网膜血管渗透性
4. Novel method for edge detection of retinal vessels based on the model of the retinal vascular network and mathematical morphology [C] . Lei Xu, Zhejiang Univ., Hangzhou, International Symposium on Multispectral Image Processing (ISMIP'98) . 1998

机译：基于视网膜血管网络模型和数学形态学的视网膜血管边缘检测新方法
5. Mechanisms of action of insulin-like growth factor binding protein-3 in promoting repair in ischemic retinal vascular mouse injury models . [D] . Kielczewski, Jennifer Lee. 2010

机译：胰岛素样生长因子结合蛋白3促进缺血性视网膜血管损伤模型修复的作用机制。
6. Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen‐induced retinopathy with its bioactive components preventing VEGF‐induced retinal vascular hyperpermeability [O] . Eunsoo Jung, Woo Kwon Jung, Su‐Bin Park, 2020

机译：优质粳米提取物可在氧致视网膜病变的小鼠模型中抑制视网膜新血管形成其生物活性成分可防止VEGF引起的视网膜血管通透性过高
7. Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen‐induced retinopathy, with its bioactive components preventing VEGF‐induced retinal vascular hyperpermeability [O] . Eunsoo Jung, Woo Kwon Jung, Su‐Bin Park, 2020

机译：Aucuba japonica提取物在氧诱导的视网膜病变小鼠模型中抑制视网膜新生血管，其生物活性组分预防VEGF诱导的视网膜血管超透性
8. Blocking Vascular Hyperpermeability, the Initiation Step of Tumor Angiogenesis Inhibits Mammary Tumor [R] . Mukhopadhyay, D. 2002

机译：阻断血管通透性过高，肿瘤血管生成的起始步骤抑制乳腺肿瘤

A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema

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