Synthesis and in vitro Study of Some New Bis(thiadiazolyl-2H-pyrazolo[3,4-d][1,3]thiazole)- methanes as Potential Nematicides

摘要

A new series of bis(pyrazolo[3,4-d][1,3]thiazoles) 7a-j has been synthesized and characterized via IR,~1H NMR,~(13)C NMR, MS and elemental analyses. All the newly synthesized compounds 7a-j have been assayed for their nematicidal activity against Ditylenchus myceliophagus and Caenorhabditis elegans by aqueous in vitro screening technique. The screened data reveal that the compound 7e is most effective against D. myceliophagus and C. elegans with LD_(50) of 160 and 180 ppm respectively and is almost equal to the activity of the standard levamisole. The compounds 7h and 7j are also most active against C. elegans with LD_(50) of 190 ppm and D. myceliophagus with LD_(50) of 180 ppm, respectively. Further, 7a-j were screened for their antibacterial activity. Most of these new compounds showed potent activity against the test bacteria and emerged as potential molecules for further development.