SUPPRESSION OF ANG II AFTER ACUTE SALINE LOAD ASSOCIATED WITH THE CHANGES OF PLASMA ANP AND SODIUM METABOLISM IN SALT-SENSITIVE HYPERTENSION PATENTS

摘要

Objective To observe the changes of plasma Ang II, ANP and their relationship with urine sodium excretion in salt sensitive hypertension. Methods The salt sensitivity was determined by acute saline loading test in 173 primary hypertensives of Stage I or Stage II. Plasma Ang II and ANP was determined by radioimmunoassay. Results After acute salt load, Ang II was suppressed inadequately. The plasma ANP secretion was not increased. The urine sodium excretion was delayed, Na~+ in RBC was increased in salt sensitive subjects. The plasma ANP was decreed in the salt sensitive subjects without Ang II suppressed. The 24 hours urine sodium excretion was lower than those Ang II suppressed. Conclusion The changes of plasma RAS are not homogeneous after salt load. Those without the plasma Ang II suppressed have more severe sodium metabolism abnormalities and the endogenous ANP secretion is impaired in salt sensitive patients.