High-resolution dynamic computer simulation of electrophoresis using a multiphysics software platform

摘要

Highlights?COMSOL Multiphysics was extended with an interface for electrophoresis simulations.?Benchmark simulations of electrophoretic configurations were performed in 1D.?Results are in agreement to those obtained by two well-characterized 1D simulators.?The model accurately describes the dynamics of electrophoretic procedures.AbstractThe modeling and simulation software COMSOL Multiphysics?was recently extended with an electrophoretic transport interface. Its performance was investigated by comparison to results obtained using the 1D dynamic electrophoresis simulators GENTRANS and SIMUL5. Simulations of zone electrophoresis, isotachophoresis, isoelectric focusing and of an oscillating electrolyte system were performed. Smooth profiles were essentially identical indicating that the COMSOL electrophoretic transport interface is able to reproduce results of the 1D simulato