HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Shah Manish A.; Xu Rui-hua; Bang Yung-Jue; Hoff Paulo M.; Liu Tianshu; Herraez-Baranda Luis A.; Xia Fan; Garg Amit; Shing Mona; Tabernero Josep

首页> 外文期刊>Journal of Clinical Oncology >HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

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HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

机译：Hearoise：IIIB阶段随机化多中心研究比较与人体表皮生长因子受体2阳性转移性胃或胃食管反应腺癌腺癌腺癌腺癌腺癌腺癌患者的一线治疗和高剂量曲妥珠单抗

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来源
《Journal of Clinical Oncology》 |2017年第22期|共16页
作者
Shah Manish A.; Xu Rui-hua; Bang Yung-Jue; Hoff Paulo M.; Liu Tianshu; Herraez-Baranda Luis A.; Xia Fan; Garg Amit; Shing Mona; Tabernero Josep;
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作者单位

Weill Cornell Med Coll Meyer Canc Ctr Med Oncol Solid Tumor Program New York NY USA;

Sun Yat Sen Univ Canc Ctr State Key Lab Oncol South China Guangzhou Guangdong Peoples R China;

Seoul Natl Univ Coll Med Seoul South Korea;

Hosp Sirio Libanes Sao Paulo Brazil;

Fudan Univ Zhongshan Hosp Shanghai Peoples R China;

F Hoffmann La Roche Ltd Basel Switzerland;

Roche China Holding Ltd Shanghai Peoples R China;

Genentech Inc San Francisco CA 94080 USA;

Genentech Inc San Francisco CA 94080 USA;

Univ Autonoma Barcelona Vall dHebron Univ Hosp Barcelona Spain;

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正文语种 eng
中图分类肿瘤学;
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1. HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [J] . Shah Manish A., Xu Rui-hua, Bang Yung-Jue, Journal of Clinical Oncology . 2017,第22期

机译：Hearoise：IIIB阶段随机化多中心研究比较与人体表皮生长因子受体2阳性转移性胃或胃食管反应腺癌腺癌腺癌腺癌腺癌腺癌患者的一线治疗和高剂量曲妥珠单抗
2. Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study. [J] . Andersson M, Lidbrink E, Bjerre K, Journal of Clinical Oncology . 2011,第3期

机译：III期随机研究将Docetaxel Plus Trastuzumab与Vinorelbine Plus Trastuzumab相比作为转移性或局部晚期人体表皮生长因子受体2阳性乳腺癌的一线治疗：Hernata研究。
3. Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study. [J] . Andersson M, Lidbrink E, Bjerre K, Journal of Clinical Oncology . 2011,第3期

机译：III期随机研究将Docetaxel Plus Trastuzumab与Vinorelbine Plus Trastuzumab相比作为转移性或局部晚期人体表皮生长因子受体2阳性乳腺癌的一线治疗：Hernata研究。
4. Comparison of efficacy and safety of first-line palliative chemotherapy with EOX and mDCF regimens in patients with locally advanced inoperable or metastatic HER2-negative gastric or gastroesophageal junction adenocarcinoma: a randomized phase 3 trial [O] . Sebastian Ochenduszko, Miroslawa Puskulluoglu, Kamil Konopka, -1

机译：一线姑息化疗联合EOX和mDCF方案对局部晚期无法手术或转移性HER2阴性胃或胃食管交界性腺癌患者的疗效和安全性比较：一项3期随机研究
5. Phase III, Double-Blind, Randomized Trial That Compared Maintenance Lapatinib Versus Placebo After First-Line Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer [O] . Powles, Thomas, Huddart, Robert A, Elliott, Tony, 2017

机译：III期双盲，随机试验，比较了人表皮生长因子受体1/2阳性转移性膀胱癌患者在一线化疗后维持拉帕替尼与安慰剂的疗效

HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

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