Solubility Behavior of 2-Chloro-3-(trifluoromethyl)pyridine in (Ethyl Acetate plus n-Butanol, DMF plus n-Butanol, DMF plus Ethanol) Solvent Mixtures

摘要

The solubility of 2-chloro-3-(trifluoromethyl)pyridine in ethyl acetate + n-butanol, DMF + n-butanol, and DMF + ethanol solvent mixtures was determined via an isothermal static method within the temperature scope of 263.15-303.15 K under 101.3 KPa. The solubility of 2-chloro-3-(trifluoromethyl)pyridine increased with increasing temperature and mass fraction of ethyl acetate or DMF in the binary solvent systems. The modified Apelblat model, Jouyban-Acree model, and Sun model were used to correlate the solubility data of 2-chloro-3-(trifluoromethyl)pyridine in the binary mixtures. The values of RD and RMSD indicated that three models fit the solubility data quite well, and the Sun model gave the best correlation of the solubility data in the binary ethyl acetate + n-butanol and DMF + n-butanol solvents. The Apelblat model gave the best correlation of the solubility data in the binary DMF + ethanol solvent.