Genetic factors associatedwith severe cutaneous adverse reactions

摘要

The study by Dr Chung and colleagues identified CYP2C variants, which participate in drug clearance, as important genetic factors associated with phenytoin-related severe cutaneous adverse reactions. Nevertheless, their analysis did not take into account the potential influence of coadministered drugs. For this reason, I would like to comment on the importance of drug interactions in pharmaco-genetic studies, which are designed to examine the influence of certain genetic variants on drug pharmacokinetics (eg, pharmacological and/or toxic dose-dependent activity).