Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups

Jacob Saya; Nodzenski Michael; Reisetter Anna C.; Bain James R.; Muehlbauer Michael J.; Stevens Robert D.; Ilkayeva Olga R.; Lowe Lynn P.; Metzger Boyd E.; Newgard Christopher B.; Scholtens Denise M.; Lowe William L. Jr.

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Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups

机译：靶向的代谢组学证明了在四个祖先群体怀孕期间与BMI，葡萄糖和胰岛素敏感性相关的明显和重叠的母体代谢物

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《Diabetes care》 |2017年第7期|共9页
作者
Jacob Saya; Nodzenski Michael; Reisetter Anna C.; Bain James R.; Muehlbauer Michael J.; Stevens Robert D.; Ilkayeva Olga R.; Lowe Lynn P.; Metzger Boyd E.; Newgard Christopher B.; Scholtens Denise M.; Lowe William L. Jr.;
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Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Duke Univ Med Ctr Sarah W Stedman Nutr &

Metab Ctr Durham NC USA;

Duke Univ Med Ctr Sarah W Stedman Nutr &

Metab Ctr Durham NC USA;

Duke Univ Med Ctr Sarah W Stedman Nutr &

Metab Ctr Durham NC USA;

Duke Univ Med Ctr Sarah W Stedman Nutr &

Metab Ctr Durham NC USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Duke Univ Med Ctr Sarah W Stedman Nutr &

Metab Ctr Durham NC USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups [J] . Jacob Saya, Nodzenski Michael, Reisetter Anna C., Diabetes care . 2017,第7期

机译：靶向的代谢组学证明了在四个祖先群体怀孕期间与BMI，葡萄糖和胰岛素敏感性相关的明显和重叠的母体代谢物
2. Each degree of glucose intolerance in pregnancy predicts distinct trajectories of β-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum [J] . KramerC.K., SwaminathanB., HanleyA.J., Diabetes care . 2014,第12期

机译：妊娠中葡萄糖的不同程度的耐受性可预测产后前3年中β细胞功能，胰岛素敏感性和血糖的不同轨迹
3. Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity. [J] . Luo ZC, Delvin E, Fraser WD, Diabetes care . 2010,第9期

机译：孕妇的葡萄糖耐量会影响胎儿的胰岛素敏感性。
4. Relationship between pregnancy outcome and maternal BMI and weight gain [C] . Maryam-sadat Hosseini, Jameie Nastaran World Congress on Fertility and Sterility . 2004

机译：妊娠结局与母体BMI与体重增加的关系
5. Development and application of metabolomic techniques for identification and quantification of intercellular metabolites relevant to glucose stimulated insulin secretion in beta-cells. [D] . Lorenz, Matthew A. 2011

机译：代谢组学技术的开发和应用，用于鉴定和定量与β细胞中葡萄糖刺激的胰岛素分泌有关的细胞间代谢物。
6. Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI Glucose and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups [O] . Saya Jacob, Michael Nodzenski, Anna C. Reisetter, 2017

机译：有针对性的代谢组学研究表明在四个祖先组的妊娠期间与BMI葡萄糖和胰岛素敏感性相关的母体代谢产物存在明显的重叠。
7. Peroxisome Proliferator-Activated Receptor-α Activation during Pregnancy Attenuates Glucose-Stimulated Insulin Hypersecretion in Vivo by Increasing Insulin Sensitivity, without Impairing Pregnancy-Induced Increases in β-Cell Glucose Sensing and Responsiveness [O] . Mary C. Sugden, Gemma K. Greenwood, Nicholas D. Smith, 2003

机译：通过增加胰岛素敏感性，妊娠期间过氧化物酶促增殖物激活的受体-α活化衰减体内血糖刺激的胰岛素高度，而不会损害妊娠诱导的β-细胞葡萄糖感测和反应性增加

Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups

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