Differential Role of B Cells and IL-17 Versus IFN-gamma During Early and Late Rejection of Pig Islet Xenografts in Mice

Kang Hee Kap; Wang Shusen; Dangi Anil; Zhang Xiaomin; Singh Amar; Zhang Lei; Rosati James M.; Suarez-Pinzon Wilma; Deng Xuelian; Chen Xiaoyan; Thorp Edward B.; Hering Bernhard J.; Miller Stephen D.; Luo Xunrong

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Differential Role of B Cells and IL-17 Versus IFN-gamma During Early and Late Rejection of Pig Islet Xenografts in Mice

机译：B细胞和IL-17与IFN-Gamma的差异作用早期和晚期抑制小鼠猪胰岛异种移植物

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Background Xenogeneic islet transplantation is an emerging therapeutic option for diabetic patients. However, immunological tolerance to xenogeneic islets remains a challenge.

机译：背景，糖尿病患者是一种新兴治疗选择。然而，对异种岛的免疫耐受性仍然是一个挑战。

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《Transplantation: Official Journal of the Transplantation Society》 |2017年第8期|共10页
作者
Kang Hee Kap; Wang Shusen; Dangi Anil; Zhang Xiaomin; Singh Amar; Zhang Lei; Rosati James M.; Suarez-Pinzon Wilma; Deng Xuelian; Chen Xiaoyan; Thorp Edward B.; Hering Bernhard J.; Miller Stephen D.; Luo Xunrong;
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作者单位

Northwestern Univ Feinberg Sch Med Div Nephrol &

Hypertens Chicago IL 60611 USA;

Nankai Univ Tianjin Union Med Ctr Affiliated Hosp Tianjin Peoples R China;

Northwestern Univ Feinberg Sch Med Div Nephrol &

Hypertens Chicago IL 60611 USA;

Northwestern Univ Dept Surg Feinberg Sch Med Comprehens Transplant Ctr Chicago IL 60611 USA;

Univ Minnesota Dept Surg Schulze Diabet Inst Box 242 UMHC Minneapolis MN 55455 USA;

Northwestern Univ Feinberg Sch Med Div Nephrol &

Hypertens Chicago IL 60611 USA;

Northwestern Univ Feinberg Sch Med Div Nephrol &

Hypertens Chicago IL 60611 USA;

Univ Minnesota Dept Surg Schulze Diabet Inst Box 242 UMHC Minneapolis MN 55455 USA;

Guangzhou Med Univ Affiliated Hosp 1 Div Endocrinol Guangzhou Guangdong Peoples R China;

Guangzhou Med Univ Affiliated Hosp 1 Div Endocrinol Guangzhou Guangdong Peoples R China;

Northwestern Univ Dept Pathol Feinberg Sch Med Chicago IL 60611 USA;

Univ Minnesota Dept Surg Schulze Diabet Inst Box 242 UMHC Minneapolis MN 55455 USA;

Northwestern Univ Dept Microbiol &

Immunol Feinberg Sch Med Interdept Immunobiol Ctr Chicago;

Northwestern Univ Feinberg Sch Med Div Nephrol &

Hypertens Chicago IL 60611 USA;

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正文语种 eng
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专利

1. Differential Role of B Cells and IL-17 Versus IFN-gamma During Early and Late Rejection of Pig Islet Xenografts in Mice [J] . Kang Hee Kap, Wang Shusen, Dangi Anil, Transplantation: Official Journal of the Transplantation Society . 2017,第8期

机译：B细胞和IL-17与IFN-Gamma的差异作用早期和晚期抑制小鼠猪胰岛异种移植物
2. Adoptive transfer of xenoantigen-stimulated T cell receptor V beta-restricted human regulatory T cells prevents porcine islet xenograft rejection in humanized mice [J] . Jin Xi, Hu Min, Gong Lina, Molecular medicine reports . 2018,第5期

机译：Xenoantigen刺激的T细胞受体Vβ受限的人类调节T细胞的养曲型转移可防止人源化小鼠中的猪胰岛异种移植物排斥反应
3. Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles. [J] . Xu BY, Yang H, Serreze DV, Transplantation: Official Journal of the Transplantation Society . 2005,第3期

机译：NOD小鼠对破坏的胰岛异种移植物的快速破坏是CD4依赖性的，并由B细胞促进：先天免疫和自身免疫没有显著作用。
4. CXCL 12-delivery by double microcapsules and dual costimulatory blockade synergistically prolong the survival of porcine islet xenografts in diabetic NOD mice [C] . Susan Safley, Graham F Barber, Stephanie M Duncanson, World biomaterials congress . 2016

机译：双重微胶囊和双重共刺激封锁的CXCL 12传递协同延长了糖尿病NOD小鼠的猪胰岛异种移植的存活时间。
5. Mechanisms of neonatal porcine islet xenograft rejection [D] . Mok, Dereck Cherk-Ming 2009

机译：新生儿猪胰岛异种移植物排斥的机制
6. Differential role of B cells and IL-17 versus IFN-γ during early and late rejection of pig islet xenografts in mice [O] . Hee Kap Kang, Shusen Wang, Anil Dangi, -1

机译：小鼠胰岛异种移植早期和晚期排斥反应中B细胞和IL-17与IFN-γ的差异作用
7. Adoptive transfer of xenoantigen‑stimulated T cell receptor Vβ‑restricted human regulatory T cells prevents porcine islet xenograft rejection in humanized mice [O] . Xi Jin, Min Hu, Lina Gong, 2018

机译：Xenoantigen刺激的T细胞受体Vβ限制的人体调节T细胞的养老转移可防止人源化小鼠中的猪胰岛异种移植物排斥反应
8. Differential Processing of Cyclin E Variants in Normal Versus Tumor Cells and Their Role in Breast Cancer Oncogenesis [R] . McGahren, M. J. , Keyomarsi, K. 2002

机译：正常与肿瘤细胞周期蛋白E变异体的差异加工及其在乳腺癌发生中的作用

Differential Role of B Cells and IL-17 Versus IFN-gamma During Early and Late Rejection of Pig Islet Xenografts in Mice

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