Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

Steines Louisa; Poth Helen; Schuster Antonia; Geissler Edward K.; Amann Kerstin; Banas Bernhard; Bergler Tobias

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Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

机译：抗BAFF治疗干扰大鼠肾移植模型中的体液反应

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Background. B-cell-activating factor (BAFF) is associated with donor-specific antibodies (DSA) and poorer outcomes after renal transplantation (RTx). We examined the effects of anti-BAFF treatment on B cells, expression of costimulatory molecules and cytokines, germinal centers (GCs), and DSA formation in an RTx model in rats.

机译：背景。 B细胞活化因子（BAFF）与肾移植（RTX）后的供体特异性抗体（DSA）和较差的结果相关。我们研究了对B细胞的抗BAFF治疗的影响，在大鼠RTX模型中表达了共刺激分子和细胞因子，发芽中心（GCS）和DSA形成的表达。

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《Transplantation: Official Journal of the Transplantation Society》 |2020年第1期|共7页
作者
Steines Louisa; Poth Helen; Schuster Antonia; Geissler Edward K.; Amann Kerstin; Banas Bernhard; Bergler Tobias;
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Univ Hosp Regensburg Dept Nephrol Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

Univ Hosp Regensburg Dept Nephrol Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

Univ Hosp Regensburg Dept Nephrol Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

Univ Hosp Regensburg Dept Surg Regensburg Germany;

Univ Hosp Erlangen Dept Nephropathol Erlangen Germany;

Univ Hosp Regensburg Dept Nephrol Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

Univ Hosp Regensburg Dept Nephrol Franz Josef Strauss Allee 11 D-93053 Regensburg Germany;

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1. Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats [J] . Steines Louisa, Poth Helen, Schuster Antonia, Transplantation: Official Journal of the Transplantation Society . 2020,第1期

机译：抗BAFF治疗干扰大鼠肾移植模型中的体液反应
2. Humoral and Cellular Responses to a Single Dose of Fendrix in Renal Transplant Recipients with Non-response to Previous Hepatitis B Vaccination [J] . Lindemann M., Zaslavskaya M., Fiedler M., Scandinavian journal of immunology. . 2017,第1期

机译：对肾移植受者在肾移植受者的单剂量和细胞反应对先前的乙型肝炎疫苗接种的肾移植受者的反应
3. Rat renal transplant model for mixed acute humoral and cellular rejection: Weak correlation of serum cytokines/chemokines with intragraft changes [J] . Lemke Anja, Noriega Mercedes, Roeske Anja M., Transplant immunology . 2015,第2期

机译：急性体液和细胞排斥反应的大鼠肾脏移植模型：血清细胞因子/趋化因子与移植物内变化的弱相关性
4. RISK-ADAPTED MELPHALAN WITH STEM CELL TRANSPLANT (SCT) AND ADJUVANT DEXAMETHASONE (DEX) +/- THALIDOMIDE (THAL) ACHIEVES LOW TREATMENT-RELATED MORTALITY AND HIGH HEMATOLOGIC RESPONSE RATES [C] . AD Cohen, P Zhou, L Reich, International Symposium on Amyloidosis . 2008

机译：具有干细胞移植（SCT）和佐剂地塞米松（DEX）+/-沙利度胺（THAL）的风险适应的Melphalan实现了低治疗相关死亡率和高血液应答率
5. Humoral Response to Carbohydrate Antigens in the Context of ABO-Incompatible Transplantation and Xenotransplantation. [D] . Kandeva, Teodora N. 2008

机译：在ABO不相容移植和异种移植的背景下对碳水化合物抗原的体液反应。
6. Cell-mediated and humoral immune responses to herpes simplex virus and cytomegalovirus in renal transplant patients. [O] . S Haahr, A Møller-Larsen, H K Andersen, 1979

机译：肾移植患者对单纯疱疹病毒和巨细胞病毒的细胞介导和体液免疫反应。
7. A prospective cohort study of incident maintenance dialysis in children: An NAPRTC study11The North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) is a voluntary collaborative effort comprising over 150 pediatric renal disease treatment centers in the United States, Canada, Mexico and Costa Rica. It is supported by major, unrestricted educational grants from Novartis, AMGEN, and Genentech. Participating NAPRTCS Centers are listed in the most recent NAPRTCS Annual Report Seikaly M, Ho PL, Emmet L, Tejani A: The 12th Annual Report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS): Renal Transplantation from 1987 through 1998. Pediatr Transplant 5:215–231, 2001. [O] . Leonard Mary B., Donaldson Lynn A., Ho Martin, 2003

机译：儿童事件维持性透析的前瞻性队列研究：NAPRTC研究11北美小儿肾脏移植合作研究（NAPRTCS）是一项自愿合作，由美国，加拿大，墨西哥和哥斯达黎加的150多个小儿肾脏疾病治疗中心组成。它得到了诺华，AMGEN和Genentech的重大无限制教育资助的支持。最新的NAPRTCS年度报告中列出了参与的NAPRTCS中心Seikaly M，Ho PL，Emmet L，Tejani A：《北美小儿肾脏移植合作研究》（NAPRTCS）第12份年度报告：1987年至1998年的肾脏移植。Pediatr移植5：215-231，2001。

Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

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