Pathogen safety of a pasteurized four-factor human prothrombin complex concentrate preparation using serial 20N virus filtration

摘要

BACKGROUND: Beriplex P/N/Kcentra/Coaplex/Confidex is a four-factor human prothrombin complex concentrate (PCC). Here, we describe the pathogen safety profile and biochemical characteristics of an improved manufacturing process that further enhances the virus safety of Beriplex P/N.