FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

Beukers Willemien; van der Keur Kirstin A.; Kandimalla Raju; Vergouwe Yvonne; Steyerberg Ewout W.; Boormans Joost L.; Jensen Jorgen B.; Lorente Jose A.; Real Francisco X.; Segersten Ulrike; Orntoft Torben F.; Malats Nuria; Malmstrom Per-Uno; Dyrskjot Lars; Zwarthoff Ellen C.

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FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

机译：FGFR3，TERT和OTX1作为尿生物标志物组合，用于在大型前瞻性多中心研究中进行膀胱癌患者的监测

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Purpose: Patients with nonmuscle invasive bladder cancer are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 were investigated as a diagnostic urinary marker combination during followup of patients with primary nonmuscle invasive bladder cancer.

机译：目的：伴随着非血液侵入性膀胱癌的患者常见的膀胱镜。在该研究中，在初级非血液侵袭性膀胱癌的患者随访期间，研究了TERT和OTX1作为诊断尿标志物组合。

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来源
《The Journal of Urology》 |2017年第6期|共8页
作者
Beukers Willemien; van der Keur Kirstin A.; Kandimalla Raju; Vergouwe Yvonne; Steyerberg Ewout W.; Boormans Joost L.; Jensen Jorgen B.; Lorente Jose A.; Real Francisco X.; Segersten Ulrike; Orntoft Torben F.; Malats Nuria; Malmstrom Per-Uno; Dyrskjot Lars; Zwarthoff Ellen C.;
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作者单位

Erasmus MC Dept Pathol POB 2040 NL-3000 CA Rotterdam Netherlands;

Erasmus MC Dept Pathol POB 2040 NL-3000 CA Rotterdam Netherlands;

Erasmus MC Dept Pathol POB 2040 NL-3000 CA Rotterdam Netherlands;

Erasmus MC Dept Publ Hlth Rotterdam Netherlands;

Erasmus MC Dept Publ Hlth Rotterdam Netherlands;

Erasmus MC Dept Urol Rotterdam Netherlands;

Aarhus Univ Hosp Dept Urol Aarhus Denmark;

Hosp del Mar Serv Urol Barcelona Spain;

Univ Pompeu Fabra Dept Ciencies Expt &

Salut Barcelona Spain;

Uppsala Univ Dept Surg Sci Uppsala Sweden;

Aarhus Univ Hosp Dept Mol Med Aarhus Denmark;

Spanish Natl Canc Res Centre CNIO Canc Cell Biol Programme Epithelial Carcinogenesis Grp Madrid;

Uppsala Univ Dept Surg Sci Uppsala Sweden;

Aarhus Univ Hosp Dept Mol Med Aarhus Denmark;

Erasmus MC Dept Pathol POB 2040 NL-3000 CA Rotterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
urinary bladder neoplasms; neoplasm recurrence; local; urinalysis; cystoscopy; neoplasm invasiveness;

机译：膀胱肿瘤;肿瘤复发;局部;尿液分析;膀胱镜检查;肿瘤侵袭性;

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专利

1. FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study REPLY [J] . The Journal of Urology . 2017,第6期

机译：FGFR3，TERT和OTX1作为尿生物标志物组合，用于在大型前瞻性多中心研究回复中进行膀胱癌患者的监测
2. FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study EDITORIAL COMMENTS [J] . de Reijke Theo M. The Journal of Urology . 2017,第6期

机译：FGFR3，TERT和OTX1作为在大型潜在多中心研究中膀胱癌患者监测的尿生物标志物组合编辑评论
3. FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study EDITORIAL COMMENTS [J] . Grossman H. Barton The Journal of Urology . 2017,第6期

机译：FGFR3，TERT和OTX1作为在大型潜在多中心研究中膀胱癌患者监测的尿生物标志物组合编辑评论
4. Improved diagnosis and therapy of superficial transitional cell carcinoma (TCC) of the urinary bladder by 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PPIX) fluorescence: a prospective study in 100 patients [C] . Rainer M. Kuntz, Frank Rucker Conference on lasers in surgery: Advanced characterization, therapeutics, and systems XI . 2001

机译：5-氨基乙酰丙酸（5-ALA）诱导的原卟啉IX（PPIX）荧光改善了膀胱浅表移行细胞癌（TCC）的诊断和治疗：一项对100例患者的前瞻性研究
5. Cystoscopy and the development of invasive bladder cancer in patients presenting with superficial urinary bladder cancer. [D] . Amos, Charles E., Jr. 2003

机译：膀胱镜检查和浅表性膀胱癌患者的浸润性膀胱癌的发展。
6. TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer [O] . Kun Wang, Tiantian Liu, Cheng Liu, 2015

机译：TERT启动子突变和TERT mRNA但不是FGFR3突变是中国汉族人膀胱膀胱癌患者的尿液生物标志物
7. Supplementary Material for: Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer [O] . Roperch, Jean-Pierre, Grandchamp, Bernard, Desgrandchamps, François, 2016

机译：补充材料：HS3ST2，SEPTIN9和SLIT2的启动子高甲基化结合FGFR3突变，作为敏感/特异的尿液测定法，可用于低危或高危非肌肉浸润性膀胱癌患者的诊断和监测

FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

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