A Four-Component Reaction for the Synthesis of beta-Quinoline Allylic Sulfones under Iron Catalysis

摘要

An efficient strategy for the preparation of allylic sulfones has been developed. In this protocol, readily available 2-methylquinolines or 2-methylbenzothiazoles, sodium sulfinates, and dimethylacetamide (DMA) were successfully assembled under user-friendly iron catalysis, and DMA provided two carbons as a dual synthon. A broad range of functionalized heterocyclic allylic sulfones were accessed with a wide functional group tolerance.