Cardiopulmonary Adaptation During First Day of Life in Human Neonates

摘要

ObjectiveTo characterize the natural history of cardiopulmonary physiology in the first 24 hours after birth. Study designA prospective observational study of healthy newborns was conducted at a large tertiary perinatal center. Echocardiography was performed at <0.5, 2-3, 7-10, and 22-24 hours of age. Specifically, assessment of pulmonary vascular resistance (PVR) (pulmonary artery acceleration time [PAAT], right ventricular ejection time, right ventricular ejection time:PAAT [PVR index], and PAAT indexed to heart rate [PAATi]), ventricular outputs (right and left), and ventricular function (tricuspid annular planar excursion, right ventricular [RV] fractional area change [FAC], RV/left ventricular [LV] global peak longitudinal strain, and LV ejection fraction) were performed. One-way repeated-measures ANOVA analysis was performed for time-dependent variables. ResultsIn total, 15 neonates (9 males), born at 40?±?0.8 weeks and 3.5?±?0.5 kg, respectively, were studied. We observed increased PAATi (P?