NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis

Leopold Donald A.; Elkayam David; Messina John C.; Kosik-Gonzalez Colette; Djupesland Per G.; Mahmoud Ramy A.

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NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis

机译：导航II：随机，双盲试验，滴水输送系统与鼻息酸滴水

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Background: Chronic rhinosinusitis is common and sometimes complicated by nasal polyps (NPs). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation.

机译：背景：慢性鼻窦炎是常见的，有时被鼻息肉（NPS）复杂化。皮质类固醇鼻腔喷雾往往不令人满意，因为它们在将药物递送到炎症的高/深部位时是无效的。

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来源
《The Journal of Allergy and Clinical Immunology》 |2019年第1期|共14页
作者
Leopold Donald A.; Elkayam David; Messina John C.; Kosik-Gonzalez Colette; Djupesland Per G.; Mahmoud Ramy A.;
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作者单位

Univ Vermont Dept Surg Coll Med 111 Colchester Ave Main Campus West Pavil Level 4 Burlington;

Bellingham Asthma Allergy &

Immunol Clin Bellingham WA USA;

OptiNose US Yardley PA USA;

OptiNose US Yardley PA USA;

OptiNose AS Oslo Norway;

OptiNose US Yardley PA USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Sinusitis; nasal polyps; intranasal drug; corticosteroids; fluticasone; inflammation;

机译：鼻窦炎;鼻息肉;鼻内药物;皮质类固醇;氟替卡松;炎症;

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专利

1. NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis [J] . Leopold Donald A., Elkayam David, Messina John C., The Journal of Allergy and Clinical Immunology . 2019,第1期

机译：导航II：随机，双盲试验，滴水输送系统与鼻息酸滴水
2. NAVIGATE 2: FLU-EDS (FLUTICASONE EXHALATION DELIVERY SYSTEM) FOR SYMPTOMS OF CHRONIC RHINOSINUSITIS WITH NASAL POLYPS [J] . Elkayam D., Greos L., Messina J., Annals of allergy, asthma, and immunology . 2016,第5Suppla1期

机译：导航2：Flu-EDS（氟替卡松排泄系统），用于鼻息肉的慢性鼻窦炎症状
3. A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol [J] . John C. Messina, Elliot Offman, Jennifer L Carothers, Clinical therapeutics . 2019,第11期

机译：通过Xhance呼气输送系统输送的氟替卡松丙酸酯的药代动力学和生物利用度随机比较鼻腔喷雾和短暂的HFA吸入气溶胶
4. Prospective, double-blind, randomized trial evaluating subject pain, bleeding, and wound healing using biodegradable pure collagen sponge(Colladerm~®) as endo-nasal packing materials in nasal bone fracture surgery [C] . Kangyoung Choi, Gyusik Jung, Inkook Jo World biomaterials congress . 2016

机译：使用可生物降解的纯胶原海绵（Colladerm〜®）作为鼻骨骨折手术中的鼻内填充材料的前瞻性，双盲，随机试验，用于评估受试者的疼痛，出血和伤口愈合情况
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. NAVIGATE I: Randomized Placebo-Controlled Double-Blind Trial of theExhalation Delivery System With Fluticasone for Chronic Rhinosinusitis WithNasal Polyps [O] . Raj Sindwani, Joseph K. Han, Daniel F. Soteres, -1

机译：NAVIGATE I：随机安慰剂对照双盲试验氟替卡松呼气输送系统治疗慢性鼻鼻窦炎鼻息肉
7. NAVIGATE I: Randomized, Placebo-Controlled, Double-Blind Trial of the Exhalation Delivery System With Fluticasone for Chronic Rhinosinusitis With Nasal Polyps [O] . Raj Sindwani, Joseph K. Han, Daniel F. Soteres, 2018

机译：导航I：随机，安慰剂控制，呼出递送系统的双盲试验，促成慢性鼻窦炎，鼻息肉炎

NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis

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