Asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a diaminomethylenemalononitrile organocatalyst

摘要

A pyrrolidine-diaminomethylenemalononitrile organocatalyst efficiently promotes the asymmetric direct bisvinylogous Michael addition of 5-benzylfurfural derivatives to nitroalkenes, affording the corresponding epsilon-regioselective addition products in high yields with up to 86% ee. (C) 2017 Elsevier Ltd. All rights reserved.