Cu-catalyzed aerobic oxidative synthesis of sulfonamides from sulfonyl hydrazides and amines

摘要

An environmentally friendly route for sulfonamides has been developed. The oxidative coupling of sulfonyl hydrazides and amines was catalyzed by CuBr2 to produce various sulfonamides with the water and nitrogen gas as byproducts. Preliminary experiments revealed that the sulfonyl radical is likely to be involved in the reaction mechanism. (C) 2019 Elsevier Ltd. All rights reserved.