Novel synthesis of perfluoroalkylated indolizinylphosphonates via a DIPEA-promoted one-pot process

摘要

AbstractDIPEA-promoted one-pot synthesis of perfluoroalkylated indolizinylphosphonates by the reaction of pyridines1, bromomethyl ketones2with perfluoroalkynylphosphonates3is described. This procedure is compatible with a broad range of functional groups in both pyridines and ketones with good yields. The reaction proceeds through a tandem CN bond formation followed by an intramolecular cyclization.Graphical abstractDIPEA-promoted one-pot synthesis of perfluoroalkylated indolizinylphosphonates by the reaction of pyridines1, bromomethyl ketones2with perfluoproalkynylphosphonates3is described. This procedure is compatible with a broad range of functional groups in both pyridines and ketones with good yields. The reaction proceeds through a tandem CN bond formation followed by an intramolecular cyclization.Display Omitted]]>