6- p-cymene) complexes bearing N-dibenzosuberenyl appended thiourea for catalytic transfer hydrogenation and in vitro anticancer activity]]>

摘要

Four Ru(II)(η6-p-cymene) complexes of the type [RuCl2(η6-p-cymene)L] (L?=?N-dibenzosuberenyl appended aroyl/acylthiourea ligand) (1–4) were synthesized and well characterized by elemental analyses, UV–Vis, FT-IR and NMR spectroscopic methods. The neutral monodentate S coordination of the ligand with Ru(II) ion was confirmed by the single crystal X-ray diffraction method. The catalytic transfer hydrogenation (TH) of the carbonyl and nitro compounds using 2-propanol (IPA) as a hydrogen source were tested with the prepared complexes. The TH reactions progressed with good conversions up to 99% and so the use of complex4was extended to aromatic/heterocyclic carbonyl and nitro compounds. In addition to this, the synthesized complexes were evaluated for theirin vitrocytotoxic activity against human cervical cancer (HeLa), human breast cancer (MCF-7) and human lung cancer (A549) cell lines. The complex2exhibited the most potent inhibitory activity against the three cancer cell lines MCF-7, A549, HeLa with IC50values of 18.91?±?0.97, 22.78?±?1.15 and 27.22?±?1.07?μM respectively, while maintaining low toxicity towards the non-cancer originated cell line HEK-293 (Human Embryonic Kidney 293).