Schottky-like anomalies and phase transitions in ideal heteropolymer proteinogenic chains in terms of size and single-residue helical propensity

摘要

Abstract Proteins belong to a class of biological macromolecules capable to undergo thermodynamic phase transitions from random one-dimensional to three-dimensional non-periodic structures. For a large class of proteins, such configurational phase transitions can be directly associated with a passage from poor or non-biologically active states to highly biologically-active conformations. In this work we present a simple model suitable to study analytical and numerically thermodynamic properties for an ideal heteropolymer chain X 1 ? X 2 ? ? X N composed by