Synthesis of α-ketoamides from Aryl methyl ketones and N, N -dimethylformamide via copper-catalyzed aerobic oxidative coupling

摘要

A copper-catalyzed aerobic oxidative coupling of aryl methyl ketones with N,N-dimethylformamide was developed, which afforded α-ketoamides by a sequence of dioxygen activation, C-H bond functionalization, and amide formation with N,N-dimethylformamide as the nitrogen source. Molecular oxygen was found to play a crucial role in this transformation.