Synthesis of [(arylselanyl)alkyl]-1,2,3-triazoles by copper-catalyzed 1,3-dipolar cycloaddition of (arylselanyl)alkynes with benzyl azides

摘要

In the presence of catalytic amounts of copper salts and sodium ascorbate, various (arylselanyl)alkynes underwent click-type 1,3-dipolar cycloaddition reactions with a range of benzyl azides bearing electron-withdrawing or electron-donating groups to give a series of novel [(arylselanyl)alkyl]-1,2,3- triazoles. This click chemistry protocol is an efficient method for synthesizing new selenium-nitrogen compounds that are potentially useful in biological studies.