Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1λ 3,2- benziodoxol-3(1 H)-one and alkynylation of indoles, thiophenes, and anilines

摘要

An efficient procedure was developed for the synthesis of 1-[(triisopropylsilyl)ethynyl]-1 3,2-benziodoxol-3(1H)-one on a 100-mmol (36-g) scale. The benziodoxolone can be used for the gold-catalyzed direct alkynylation of indole, 2-hexylthiophene, or N,N-dibenzylaniline on a 5- to 10-mmol scale.