Intravenous Thrombolysis in Unknown-Onset Stroke Results From the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry

摘要

Background and Purpose-Stroke patients with unknown onset (UKO) are excluded from thrombolytic therapy. We aim to study the safety and efficacy of intravenous alteplase in ischemic stroke patients with UKO of symptoms compared with those treated within 4.5 hours in a large cohort.