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Dearomatization Strategies of Heteroaromatic Compounds

机译:杂芳族化合物的脱芳香化策略

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摘要

Dearomatization strategies of heteroaromatic compounds such as benzofurans,indoles, thiophe-nes, pyridines, and other heteroaromatic compounds afford the most efficient protocol for the synthesis of highly bioactive molecules, natural products and commercially available drugs. The use of these strategies has been significantly increased, which has fascinated several research groups as the dearomatization strate-gies of heteroaromatic compounds at C-2 & C-3 substitution leads to formation of numerous drug-like molecules. The recent developments in dearomatization strategies involving at C-2 & C-3 positions of various heteroaromatic compounds is discussed in this review.
机译:杂芳族化合物(例如苯并呋喃,吲哚,噻吩,吡啶和其他杂芳族化合物)的脱芳香化策略为合成高生物活性分子,天然产物和市售药物提供了最有效的方案。这些策略的使用已大大增加,这使几个研究小组着迷,因为杂芳族化合物在C-2和C-3取代时的脱芳香化策略会导致形成许多类药物分子。在这篇综述中讨论了涉及各种杂芳族化合物的C-2和C-3位置的脱芳香化策略的最新进展。

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