Annulation of beta-Enaminonitriles with Alkynes via Rh-III-Catalyzed C-H Activation: Direct Access to Highly Substituted 1-Naphthylamines and Naphtho[1,8-bc]pyridines

摘要

A Cp*Rh-III-catalyzed oxidative annulation of beta-enaminonitriles with alkynes was reported to achieve selective synthesis of polysubstituted 1-naphthylamines and naphtho[1,8-bc]pyridines via multiple C-H activations. Assisted by a naphthylamine NH2 group, 1-naphthylamines were also readily cyclized to produce naphtho[1,8-bc]pyridines. In addition, the obtained naphtho[1,8-bc]pyridine derivatives exhibit intense fluorescence in the solid state.