Palladium-Catalyzed Decarboxylative γ-Olefination of 2,5-Cyclohexadiene-1-carboxylic Acid Derivatives with Vinyl Halides

摘要

This study explores a Pd-catalyzed decarboxylative Heck-type Csp~(3)–Csp~(2) coupling reaction of 2,5-cyclohexadiene-1-carboxylic acid derivatives with vinyl halides to provide γ-olefination products. The olefinated 1,3-cyclohexadienes can be further oxidized to produce meta -alkylated stilbene derivatives. Additionally, the conjugated diene products can also undergo a Diels–Alder reaction to produce a bicyclo[2.2.2]octadiene framework.