Visible-Light Induction/Bronsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines

摘要

An efficient method merging Bronsted acid catalysis with visible-light induction for the highly enantioselective synthesis of tetrahydroquinolines has been developed. This mild process directly transforms 2-aminoenones into 2-substituted tetrahydroquinolines with excellent enantioselectivities through a relay visible-light-induced cyclization/chiral phosphoric acid-catalyzed transfer hydrogenation reaction.