N-2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis

摘要

A new method was developed to synthesize N-2-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono-and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,3-triazoles was supposed to be generated, which selectively gave the N-2-alkylation products.