TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

Li Jian; Jia Zhiqiang; Xu Wen; Guo Weidong; Zhang Mingchao; Bi Jing; Cao Yang; Fan Zhongkai; Li Gang

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TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

机译：TGN-020缓解了水肿并抑制大鼠脊髓压缩损伤后的星形胶质细胞活化和胶质瘢痕形成

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Aims: Identifying drugs that inhibit edema and glial scar formation and increase neuronal survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), a potent selective inhibitor of aquaporin 4 (AQP4), to investigate the effects of TGN-020 on SCI in Sprague-Dawley rats.

机译：目的：鉴定抑制水肿和胶质瘢痕形成的药物，增加神经元存活对于改善脊髓损伤（SCI）后的结果至关重要。在此，我们使用了2-（烟酰胺）-1,3,4-噻二唑（TGN-020），一种高效的Aquaporin 4（AQP4）的选择性抑制剂，以研究TGN-020对Sprague-Dawley大鼠SCI的影响。

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来源
《Life sciences 》 |2019年第2019期| 共10页
作者
Li Jian; Jia Zhiqiang; Xu Wen; Guo Weidong; Zhang Mingchao; Bi Jing; Cao Yang; Fan Zhongkai; Li Gang;
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作者单位

Jinzhou Med Univ Affiliated Hosp 1 Dept Orthoped Jinzhou 121000 Peoples R China;

Henan Univ Sci &

Technol Affiliated Hosp 2 Dept Spinal Surg Luoyang 471003 Peoples R China;

Jinzhou Med Univ Sch Nursing Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Affiliated Hosp 1 Dept Orthoped Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Affiliated Hosp 1 Dept Orthoped Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Key Lab Neurodegenerat Dis Liaoning Prov Dept Neurobiol Jinzhou 121000 Peoples;

Jinzhou Med Univ Affiliated Hosp 1 Dept Orthoped Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Affiliated Hosp 1 Dept Orthoped Jinzhou 121000 Peoples R China;

Tongji Univ Sch Med Shanghai Peoples Hosp 10 Dept Orthoped Shanghai 200072 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Edema; Glial scar; Spinal cord injury; TGN-020; Aquaporin 4;

机译：水肿;胶质疤痕;脊髓损伤;TGN-020;Aquaporin 4;

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专利

1. TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats [J] . Li Jian, Jia Zhiqiang, Xu Wen, Life sciences . 2019 ,第期

机译：TGN-020缓解了水肿并抑制大鼠脊髓压缩损伤后的星形胶质细胞活化和胶质瘢痕形成
2. Mdivi-1 Inhibits Astrocyte Activation and Astroglial Scar Formation and Enhances Axonal Regeneration after Spinal Cord Injury in Rats [J] . Gang Li, Yang Cao, Feifei Shen, Frontiers in Cellular Neuroscience . 2016 ,第2004期

机译：Mdivi-1抑制大鼠脊髓损伤后星形胶质细胞活化和星形胶质瘢痕形成并增强轴突再生。
3. Effect of CLIP3 Upregulation on Astrocyte Proliferation and Subsequent Glial Scar Formation in the Rat Spinal Cord via STAT3 Pathway After Injury [J] . Chen Xiaoqing, Chen Cheng, Hao Jie, Journal of Molecular Neuroscience: MN . 2018 ,第1期

机译：夹子上调对大鼠脊髓损伤后大鼠脊髓增殖和随后胶质瘢痕形成的影响
4. Local Delivery of Hepatocyte Growth Factor Reduces Glial and Fibrotic Scar Formation After Spinal Cord Injury [C] . Zhicheng Wang, Mengxi Yang, Jia Nong, Society for Biomaterials annual meeting and exposition . 2019

机译：肝细胞生长因子的局部传递减少脊髓损伤后神经胶质和纤维化疤痕形成。
5. Role of platelet-activating factor in spinal cord injury and in modulating glial cell function and viability. [D] . Hostettler-DeHoff, Mary Ellen. 2002

机译：血小板活化因子在脊髓损伤中以及在调节神经胶质细胞功能和生存力中的作用。
6. Mdivi-1 Inhibits Astrocyte Activation and Astroglial Scar Formation and Enhances Axonal Regeneration after Spinal Cord Injury in Rats [O] . Gang Li, Yang Cao, Feifei Shen, 2016

机译：Mdivi-1抑制大鼠脊髓损伤后星形胶质细胞活化和星形胶质瘢痕形成并增强轴突再生。
7. Mdivi-1 inhibits astrocyte activation and astroglial scar formation and enhances axonal regeneration after spinal cord injury in rats [O] . gang li, yang cao, feifei shen, 2016

机译：mdivi-1抑制大鼠脊髓损伤后星形胶质细胞活化和星形胶质瘢痕形成并增强轴突再生

TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

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