Inter-residue interactions in alpha-helical transmembrane proteins

摘要

Motivation The number of available membrane protein structures has markedly increased in the last years and, in parallel, the reliability of the methods to detect transmembrane (TM) segments. In the present report, we characterized inter-residue interactions in alpha-helical membrane proteins using a dataset of 3462 TM helices from 430 proteins. This is by far the largest analysis published to date.