Enantioselective Aromatic Sulfide Oxidation and Tandem Kinetic Resolution Using Aqueous H ₂2 O ₂2 and Chiral Iron–Bis(oxazolinyl)bipyridine Catalysts

摘要

> An efficient method for the oxidation of aromatic sulfides has been developed by using aqueous H ₂ O ₂ , catalyzed by the in situ generated chiral Fe/6,6′‐bis(4‐isopropyloxazolin‐2‐yl)‐2,2′‐bipyridine (bipybox‐ i Pr) complex. The corresponding sulfoxides were obtained with high enantioselectivities (up to 98.5:1.5 er ) and in good yields (up to 61?%) when the mono‐oxidation of the sulfides was performed in combination with the kinetic resolution of the sulfoxide into the sulfone.