Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease

Veening-Griffioen Desiree H.; Ferreira Guilherme S.; van Meer Peter J. K.; Boon Wouter P. C.; Gispen-de Wied Christine C.; Moors Ellen H. M.; Schellekens Huub

首页> 外文期刊>European Journal of Pharmacology: An International Journal >Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease

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Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease

机译：一些动物模型比其他动物更平等吗？阿尔茨海默病疗效动物模型平移价值的案例研究

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Clinical trial failures ( > 99%) in Alzheimer's disease are in stark contrast to positive efficacy data in animals. We evaluated the correlation between animal and clinical efficacy outcomes (cognition) in Alzheimer's disease using data from registered drugs as well as interventions tested in phase II or III clinical trials for Alzheimer's disease.

机译：阿尔茨海默病的临床试验失败（> 99％）与动物中的积极疗效数据形成鲜明对比。我们评估了使用来自注册药物的数据以及在Alzheimer疾病的II期或III型临床试验中测试的疾病中的动物和临床疗效结果（认知）之间的相关性和临床疗效结果（认知）。

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来源
《European Journal of Pharmacology: An International Journal》 |2019年第2019期|共12页
作者
Veening-Griffioen Desiree H.; Ferreira Guilherme S.; van Meer Peter J. K.; Boon Wouter P. C.; Gispen-de Wied Christine C.; Moors Ellen H. M.; Schellekens Huub;
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作者单位

Univ Utrecht Dept Pharmaceut Utrecht Inst Pharmaceut Sci Univ Weg 99 NL-3584 CG Utrecht;

Univ Utrecht Dept Pharmaceut Utrecht Inst Pharmaceut Sci Univ Weg 99 NL-3584 CG Utrecht;

Univ Utrecht Dept Pharmaceut Utrecht Inst Pharmaceut Sci Univ Weg 99 NL-3584 CG Utrecht;

Univ Utrecht Copernicus Inst Sustainable Dev Innovat Studies Princetonlaan 8a NL-3584 CB;

Med Evaluat Board Graadt van Roggenweg 500 NL-3531 AH Utrecht Netherlands;

Univ Utrecht Copernicus Inst Sustainable Dev Innovat Studies Princetonlaan 8a NL-3584 CB;

Univ Utrecht Dept Pharmaceut Utrecht Inst Pharmaceut Sci Univ Weg 99 NL-3584 CG Utrecht;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Animal model; Drug development; Efficacy model; External validity; Alzheimer's disease; Translational research;

机译：动物模型;药物开发;疗效模型;外部有效性;阿尔茨海默病;翻译研究;
入库时间 2022-08-19 17:13:46

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Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease

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