Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates.

Lihong Ning; Wei Wang; Yongju Liang; Hao Peng; Liwu Fu; Hongwu He

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Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates.

机译：O，O'-二烷基的合成和细胞毒性（[2-（取代的苯氧基）乙酰氨基]（取代的苯基）甲基}膦酸盐。

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A series of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC(50) 7.1 and 11.4牸M, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.

机译：合成了一系列O，O'-Dialkyl {[2-（取代的苯氧基）乙酰氨基]（取代的苯基）甲基}膦酸盐，并对各种人肿瘤细胞系测试它们的细胞毒性活性。一些化合物（5Q，5R，5S，5W，5X和5Y）显示出相对高的细胞毒性。特别是，化合物5X和5Q分别表现出对KB和CNE2细胞的最佳细胞毒性，分别具有IC（50）7.1和11.4米m。对KB和CNE2细胞的抑制活性甚至高于氟尿嘧啶。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2012年第2期|共6页
作者
Lihong Ning; Wei Wang; Yongju Liang; Hao Peng; Liwu Fu; Hongwu He;
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Key Laboratory of Pesticide and Chemical Biology Ministry of Education and College of Chemistry;

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正文语种 eng
中图分类药学;
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1. Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates. [J] . Lihong Ning, Wei Wang, Yongju Liang, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第2期

机译：O，O′-二烷基{[2-（取代的苯氧基）乙酰胺基]（取代的苯基）甲基}膦酸酯的合成和细胞毒性。
2. Synthesis and antimicrobial activity of some 5-(2-(morpholin-4-yl)acetamido) and/or 5-(2-(4-substituted piperazin-1-yl)acetamido)-2-(p-substituted phenyl)benzoxazoles. [J] . Temiz Arpaci O, Ozdemir A, Yalcin I, Archiv der Pharmazie . 2005,第2a3期

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Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates.

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