首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Postpolymerization modification of a hydroxy monolith precursor. Part I. Epoxy alkane and octadecyl isocyanate modified poly (hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography
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Postpolymerization modification of a hydroxy monolith precursor. Part I. Epoxy alkane and octadecyl isocyanate modified poly (hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography

机译:羟基甲型前体的后聚合改性。 第一部分。环氧烷烃和十八烷基异氰酸酯改性聚(甲基丙烯酸甲酯 - 共季戊四醇三丙烯酸酯)的反相毛细管电粒度的整体毛细管柱

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A novel precursor monolithic capillary column referred to as "hydroxy monolith" or OHM was prepared by the in situ copolymerization of hydroxyethylmethacrylate (HEMA) with pentaerythritol triacrylate (PETA) yielding the neutral poly(HEMA-co-PETA) monolith. The neutral precursor OHM capillary thus obtained was subjected to postpolymerization modifications of the hydroxyl functional groups present on its surface with 1, 2-epoxyalkanes catalyzed by boron trifluoride (BF3) ultimately providing Epoxy OHMC-m capillary column at varying alkyl chain lengths where m = 8, 12, 14, and 16 for RP-CEC. Also, the same precursor OHM was grafted with octadecyl isocyanate yielding Isocyanato OHM C-18 column to provide an insight into the effect of the nature of the linkage to the surface hydroxyl groups of the OHM precursor. While the epoxide reaction leaves on the surface of the OHM precursor hydroxy-ether linkages, the isocyanato reaction leaves carbamate linkages on the same surface of the OHM precursor. This study revealed that changing the alkyl chain length resulted in changing the column phase ratio (phi) and also the solute distribution constant (K). While increasing the surface alkyl chain length increased steeply the solute hydrophobic selectivity, i.e. methylene group selectivity, the nature of the ligand linkage produced different retention for the same solutes and affected the selectivity of slightly polar solutes. The various monoliths proved very useful for RP-CEC of different small solutes at varying polarity over a wide range of mobile phase composition.
机译:一种新颖的前体单块毛细管柱称为“羟基整料”或OHM通过用季戊四醇三丙烯酸酯得到的中性聚(HEMA - 共 - PETA)整料羟乙酯(HEMA)的原位共聚(PETA)制备。将由此获得的中性前体欧姆毛细管进行在其表面上存在的羟基官能团,其用硼三氟化硼(BF3)催化的1,2-环氧烷烃,最终在不同的烷基链长度下提供环氧型欧姆-M毛细管柱,其中M =用于RP-CEC的8,12,14和16。此外,将相同的前体欧姆用十八烷基异氰酸酯接枝异氰酸盐欧姆C-18柱,以了解欧姆前体的羟基的性质的效果。虽然环氧化物反应在欧姆前体羟基 - 醚键的表面上留下,但异氰酸酯反应在欧姆前体的同一表面上留下氨基甲酸酯键。该研究表明,改变烷基链长度导致改变柱相比(PHI)以及溶质分布常数(k)。虽然增加表面烷基链长度急剧增加溶质疏水选择性,即亚甲基选择性,配体键的性质产生了相同的溶质的不同保留,并影响了略微极性溶质的选择性。在各种流动相组合物上,各种整料对不同小溶质的不同小溶质的RP-CEC非常有用。

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