Synthesis, DNA binding and cancer cell toxicity of Cu(II)-complexes of a tricationic nitro-porphyrin or analogous porphyrins with pendant Schiff bases derived from reduction of the nitro group

摘要

Three Cu-complexes, one is containing 5-(4-Nitrophenyl)-10,15,20-tris (4-N-methylpyridinium) porphyrin ligand (labeled as CuP-1) and the others with meso-10,15,20-tris (4-N-methylpyridinium)-5-(4'-X-schiff base) porphyrin ligands (X referred to salicylaldehyde (CuP-2), o-Vanillin (CuP-3) respectively) have been successfully synthesized and well characterized. Various spectroscopic approaches indicate that three Cu-complexes could effectively bind with CT-DNA through intercalation mode, especially CuP-1, which has better binding affinity than its analogs. Moreover, the antiproliferative activity of the delegate complex CuP-1 have been studied by MTT assay, and CuP-1 exhibits gratifying cytotoxicity towards TCA8113 (tongue squanmous carcinoma) cell lines.