Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

摘要

Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed. (C) 2014 Elsevier B.V. All rights reserved.