Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand, India

摘要

In recent years, a great significant attention has been drawn to natural compounds rather than synthetic compounds due to their less side effects or without side effects in therapeutic. Present work deals with chemical composition and in vitro antibacterial activity of methanolic extracts of five ginger accessions collected from different places of Uttarakhand, India. Molecular docking is performed between phytocompounds identified through GC-MS analysis and bacterial protein PDB ID: 1QFE and PDB ID: 2VF5. By comparing the scoring results of compositions in extracts of ginger rhizomes with bacterial protein, we can infer the antibacterial activity about selected phytocompounds. Molecular-docking analysis and antimicrobial test proved that methanolic extract of ginger accession from Dharchula had strong antibacterial effects.