Synthesis, Characterization and Antimicrobial Screening of 1,3-Dione with their Metal Complexes

摘要

1-(5-Bromo-2-hydroxyphenyl)-3-(thiophen-2-yl)-propane-l,3-dione and its metal complexes has been synthesized. The functionalized 1,3-dione potentially acts as bidentate ligand and coordinate with the transition metal ions through P-diketo system. The synthesized diketone and then-transition metal complexes have been screened for in vitro antibacterial and antifungal activity using Resazurin 96 well plate method. The transition metal complexes showed moderate to excellent antimicrobial activity against all tested bacteria and fungi which constitutes a new group of compounds that can be used as potential metal derived drugs.