Carbonylative formation of N-acetyl-2,6-difluorobenzamide through N-H bond activation of 2,6-difluorobenzamide with Ni(II) complex supported with phosphine ligands

摘要

Fluorinated imide, N-acetyl-2,6-difluorobenzamide (C_6H _3F_2-2,6)C(O)NHC(O)Me _2, could be obtained through one-pot reaction of NiMe_2(PMe_3)_3 with 2,6-difluorobenzamide (C_6H_3F2-2,6)C(O)NH _2 1 in CO atmosphere. A postulated reaction mechanism via N-H bond cleavage and carbonylative reductive elimination on nickel center was partly experimentally confirmed. An important intermediate (C_6H _3F2-2,6)C(O)HNNiMe(PMe_3)_2 _3 was isolated and structurally characterized.