Ten metal complexes of vitamin B _3iacin: Spectroscopic, thermal, antibacterial, antifungal, cytotoxicity and antitumor studies of Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Pd(II), Cd(II), Pt(IV) and Au(III) complexes

摘要

Ten coordination compounds, namely Mn(NA) _2Cl _2· 4H _2O (1), Fe(NA)Cl _3(H _2O) _2 (2), Co(NA) _2(NO _3) _2·6H _2O (3), Ni(NA)Cl _2·5H _2O (4), Cu(NA)Cl _2· 3H _2O (5), Zn(NA)(NO _3) _2·H _2O (6), Pd(NA) _2Cl _2·H _2O (7), Cd(NA)Cl _2·H _2O (8), Pt(NA) _2Cl _4· 5H _2O (9) and Au(NA)Cl _3 (10) were obtained by the reactions of the corresponding transition metal salts with vitamin B3iacin (NA) in the presence of 1:4 (v:v) distilled water: methanol solvent at 70 °C for about 30 min, and their suggested structures were determined by elemental analyses, molar conductivity, (infrared, UV-vis) spectra, effective magnetic moment in Bohr magnetons, electron spin resonance (ESR), thermal analysis (TG), X-ray powder diffraction (XRD) as well as scanning electron microscopy (SEM). The results revealed that in complexes 1, 3, 7, and 9 both of two NA ligand coordinates one metal ion to form four or six coordinated structures, while in compound 10, one NA ligand coordinate to Au ~(+++) ion to form a square-planar geometry with N-bonded pyridine ligand is suggested, and (2, 4, 5, 6 and, 8) complexes have 1:1 structures. Antimicrobial and antitumor activities were assessment against some kind of (G ~+ and G ~-) bacteria, fungi and breast carcinoma cells (MCF-7-cell line).