Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors alpha and beta and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014)

Golani Lalit K.; George Christina; Zhao Sai; Raghavan Sudhir; Orr Steven; Wallace Adrianne; Wilson Mike R.; Hou Zhanjun; Matherly Larry H.; Gangjee Aleem

首页> 外文期刊>Journal of Medicinal Chemistry >Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors alpha and beta and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014)

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Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors alpha and beta and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014)

机译：新型6-取代的吡咯并[2,3-d]嘧啶硫代乙酰基抗叶酸具有修饰的氨基酸，可被叶酸受体α和β以及质子偶联的叶酸转运蛋白吸收，并被细胞吸收（第57卷，第8152页，2014年）

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《Journal of Medicinal Chemistry》 |2016年第8期|共1页
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Golani Lalit K.; George Christina; Zhao Sai; Raghavan Sudhir; Orr Steven; Wallace Adrianne; Wilson Mike R.; Hou Zhanjun; Matherly Larry H.; Gangjee Aleem;
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1. Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors alpha and beta and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014) [J] . Golani Lalit K., George Christina, Zhao Sai, Journal of Medicinal Chemistry . 2016,第8期

机译：新型6-取代的吡咯并[2,3-d]嘧啶硫代乙酰基抗叶酸具有修饰的氨基酸，可被叶酸受体α和β以及质子偶联的叶酸转运蛋白吸收，并被细胞吸收（第57卷，第8152页，2014年）
2. Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry [J] . Wang L, Cherian C, Desmoulin SK, Journal of Medicinal Chemistry . 2010,第3期

机译：嘌呤生物合成的新型6-取代的吡咯并[2,3-d]嘧啶噻吩基抗叶酸抑制剂系列的合成及其抗肿瘤活性
3. Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier [J] . Wang L., Cherian C., Kugel Desmoulin S., Journal of Medicinal Chemistry . 2012,第4期

机译：6-取代的吡咯并[2,3-d]嘧啶硫杂酰基区域异构体的合成和生物活性，作为从头嘌呤生物合成的抑制剂，对高亲和力叶酸受体和质子偶联的叶酸转运蛋白在还原的叶酸载体上的吸收具有选择性
4. The therapeutic targeting of folate recptor alpha positive tumors via folate receptor-selective novel 5-and 6- substituted pyrrolo [2,3- d] pyrimidine antifolates. [D] . Mitchell-Ryan, Shermaine Kimberly. 2015

机译：通过叶酸受体选择性新型5和6取代的吡咯并[2,3- d]嘧啶抗叶酸药物对叶酸受体α阳性肿瘤进行治疗。
5. Correction to Structure–ActivityProfiles ofNovel 6-Substituted Pyrrolo23-dpyrimidineThienoyl Antifolates with Modified Amino Acids for Cellular Uptakeby Folate Receptors α and β and the Proton-Coupled FolateTransporter [O] . LalitK. Golani, Christina George, Sai Zhao, -1

机译：结构调整活动的个人资料新型6-取代的吡咯并23-d嘧啶噻吩基抗叶酸与氨基酸修饰的细胞摄取叶酸受体α和β与质子耦合叶酸的相互作用运输者
6. Tumor Targeting with Novel 6-Substituted Pyrrolo 2,3-d Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis [O] . Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, 2016

机译：用叶酸受体α和质子偶联的叶酸转运蛋白通过细胞吸收与杂原子桥取代与杂原子桥取代的肿瘤靶向靶向杂膜取代，并抑制Novo嘌呤核苷酸生物合成

Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors alpha and beta and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014)

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