Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [Ti-45](salan)Ti(dipic)

摘要

We present a novel solid-phase based Ti-45 radiolabeling methodology and the implementation of Ti-45-PET in titanium-based antineoplastics using the showcase compound [Ti-45] (salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.