Synthesis, Characterisation and Anti-Microbial Activity Studies of Novel Dispiro-Oxindolopyrrolizidines

摘要

2-arylidene-1,3-indanediones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and proline to give a rare class of novel complex dispirooxindolopyrrolizidines in better yield under microwave irradiation than classical heating. X-ray crystal structure analysis of one of the product confirms the structure and regiochemical outcome of the cycloaddition reaction. Anti-microbial activity studies were carried out with all the newly synthesized dispiro-oxindolopyrrolizidines.