Evaluation of Water Sorption Behavior and In Vitro Blood Compatibility of Polyvinyl Alcohol Based Magnetic Bionanocomposites

摘要

In recent past magnetic bionanocomposites have shown potential in biomedical applications mainly due to their superparamagnetic and biocompatible nature. They have also established themselves as a promising class of hybrid organic-inorganic materials derived from polymers and organic/inorganic fillers. In this study biocompatible nanocomposites were prepared by in situ synthesis of magnetic nanoparticles within the polyvinyl alcohol-grafted-polymethyl methacrylate hydrogels and characterized by techniques such as FT-IR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and differential scanning calorimetry. The bionanocomposites were evaluated for water sorption behavior and in vitro biocompatibility by performing thrombus formation and hemolysis tests. The influence of chemical composition of the grafted hydrogel was investigated on water sorption behavior and in vitro blood compatibility of magnetic bionanocomposites.