Release of salicylic acid through poly(vinyl alcohol/poly(vinyl pyrrolidone) and poly(vinyl alcohol-g-N-vinyl-2-pyrrolidone) membranes

摘要

A controlled release profile of salicylic acid (SA) for transdermal administration has been developed. Poly (vinyl alcohol) (PVA) and Poly(vinyl alcohol)/Poly (vinyl pyrrolidone) (PVP) blended preparations were used to prepare the membranes by solvent-casting technique. The release of the drug from the membranes was evaluated at in vitro conditions. The effects of PVA/PVP (v/v) ratio, pH, SA concentration and temperature were investigated. 60/40 (v/v) PVA/PVP ratio was found to be the best ratio for the SA release. Increase in pH and temperature was observed to increase the transport of SA. Instead of blending PVA with PVP, N-Vinyl-2-pyrrolidone (VP) was grafted onto the PVA and the delivery performance for SA was compared with that of the blended PVA/PVP membranes. Grafted membranes gave higher transport percentages than the blended membranes. (c) 2006 Wiley Periodicals, Inc.